Growth "self-inhibition" of irbesartan desmotrope: surface intra-annular tautomer inter-conversion is the culprit.
Chem Commun (Camb)
; 60(26): 3511-3514, 2024 Mar 26.
Article
em En
| MEDLINE
| ID: mdl-38410911
ABSTRACT
The newly discovered growth self-inhibition phenomenon of tautomeric crystals is now generalized to the demostrope (form B) of irbesartan that displays intra-annular tautomerism in neutral aqueous solutions. The dynamic intra-annular tautomer inter-conversion on the surface is the key factor. Our findings provide implications for producing and engineering tautomeric materials.
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MEDLINE
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article