Flvcr1a deficiency promotes heme-based energy metabolism dysfunction in skeletal muscle.
Cell Rep
; 43(3): 113854, 2024 Mar 26.
Article
em En
| MEDLINE
| ID: mdl-38412099
ABSTRACT
The definition of cell metabolic profile is essential to ensure skeletal muscle fiber heterogeneity and to achieve a proper equilibrium between the self-renewal and commitment of satellite stem cells. Heme sustains several biological functions, including processes profoundly implicated with cell metabolism. The skeletal muscle is a significant heme-producing body compartment, but the consequences of impaired heme homeostasis on this tissue have been poorly investigated. Here, we generate a skeletal-muscle-specific feline leukemia virus subgroup C receptor 1a (FLVCR1a) knockout mouse model and show that, by sustaining heme synthesis, FLVCR1a contributes to determine the energy phenotype in skeletal muscle cells and to modulate satellite cell differentiation and muscle regeneration.
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Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Proteínas de Membrana Transportadoras
/
Células Satélites de Músculo Esquelético
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article