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Timing of initial symptom onset during milk and wheat challenges: A retrospective study.
Yanagida, Noriyuki; Minoura, Takanori; Sato, Sakura; Takahashi, Kyohei; Nagakura, Ken-Ichi; Ogura, Kiyotake; Itonaga, Takaaki; Miura, Yoko; Fusayasu, Naoko; Ebisawa, Motohiro.
Afiliação
  • Yanagida N; Department of Allergy, Clinical Research Center for Allergy and Rheumatology, NHO Sagamihara National Hospital, Kanagawa, Japan.
  • Minoura T; Department of Pediatrics, NHO Sendai Medical Center, Sendai, Japan.
  • Sato S; Department of Pediatrics, NHO Sendai Medical Center, Sendai, Japan.
  • Takahashi K; Department of Allergy, Clinical Research Center for Allergy and Rheumatology, NHO Sagamihara National Hospital, Kanagawa, Japan.
  • Nagakura KI; Department of Allergy, Clinical Research Center for Allergy and Rheumatology, NHO Sagamihara National Hospital, Kanagawa, Japan.
  • Ogura K; Department of Allergy, Clinical Research Center for Allergy and Rheumatology, NHO Sagamihara National Hospital, Kanagawa, Japan.
  • Itonaga T; Department of Allergy, Clinical Research Center for Allergy and Rheumatology, NHO Sagamihara National Hospital, Kanagawa, Japan.
  • Miura Y; Department of Allergy, Clinical Research Center for Allergy and Rheumatology, NHO Sagamihara National Hospital, Kanagawa, Japan.
  • Fusayasu N; Department of Allergy, Clinical Research Center for Allergy and Rheumatology, NHO Sagamihara National Hospital, Kanagawa, Japan.
  • Ebisawa M; Department of Allergy, Clinical Research Center for Allergy and Rheumatology, NHO Sagamihara National Hospital, Kanagawa, Japan.
Immun Inflamm Dis ; 12(2): e1174, 2024 Feb.
Article em En | MEDLINE | ID: mdl-38415948
ABSTRACT

BACKGROUND:

Allergic reactions to milk appear sooner than those to hen's eggs, irrespective of the total dose of the oral food challenges (OFCs) and type of matrices. The reported median times for the first symptom occurrence are 20-30 min with milk and 50-60 min with eggs. However, allergic reactions due to wheat have not yet been fully investigated.

METHODS:

This study retrospectively collected data from OFC for milk and wheat conducted at Sagamihara National Hospital and Sendai Medical Center from 2009 to 2023. The time from the start of the OFC to the onset of symptoms was compared between children with cow's milk and wheat allergy.

RESULTS:

Twenty-five and 13 children reacted to single-dose OFCs with milk products equivalent to 25 mL of raw cow's milk or 15 g of udon noodles, respectively. The median ages of patients with positive challenges were 1.4 and 2.8 years for milk and wheat, respectively, and the median times for the first symptom occurrence were 20 min and 53 min, respectively (p = .006).

CONCLUSION:

This multicenter study was the first to examine the time of symptom appearance during single-medium-dose milk and wheat challenges. Allergic reactions to wheat appear later than those for milk during OFC. For multiadministration OFC for wheat, the dosing interval should be longer than 60 min. Our findings can help improve the safety of OFCs.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Leite / Hipersensibilidade Idioma: En Ano de publicação: 2024 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Leite / Hipersensibilidade Idioma: En Ano de publicação: 2024 Tipo de documento: Article