Placental inflammation, oxidative stress, and fetal outcomes in maternal obesity.
Trends Endocrinol Metab
; 35(7): 638-647, 2024 Jul.
Article
em En
| MEDLINE
| ID: mdl-38418281
ABSTRACT
The obesity epidemic has led to a growing body of research investigating the consequences of maternal obesity on pregnancy and offspring health. The placenta, traditionally viewed as a passive intermediary between mother and fetus, is known to play a critical role in modulating the intrauterine environment and fetal development, and we now know that maternal obesity leads to increased inflammation, oxidative stress, and altered placental function. Here, we review recent research exploring the involvement of inflammation and oxidative stress as mechanisms impacting the placenta and fetus during obese pregnancy. Understanding them is crucial for informing strategies that can mitigate the adverse health effects of maternal obesity on offspring development and disease risk.
Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Placenta
/
Estresse Oxidativo
/
Obesidade Materna
/
Inflamação
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article