Neuronal dynamics direct cerebrospinal fluid perfusion and brain clearance.
Nature
; 627(8002): 157-164, 2024 Mar.
Article
em En
| MEDLINE
| ID: mdl-38418877
ABSTRACT
The accumulation of metabolic waste is a leading cause of numerous neurological disorders, yet we still have only limited knowledge of how the brain performs self-cleansing. Here we demonstrate that neural networks synchronize individual action potentials to create large-amplitude, rhythmic and self-perpetuating ionic waves in the interstitial fluid of the brain. These waves are a plausible mechanism to explain the correlated potentiation of the glymphatic flow1,2 through the brain parenchyma. Chemogenetic flattening of these high-energy ionic waves largely impeded cerebrospinal fluid infiltration into and clearance of molecules from the brain parenchyma. Notably, synthesized waves generated through transcranial optogenetic stimulation substantially potentiated cerebrospinal fluid-to-interstitial fluid perfusion. Our study demonstrates that neurons serve as master organizers for brain clearance. This fundamental principle introduces a new theoretical framework for the functioning of macroscopic brain waves.
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Base de dados:
MEDLINE
Assunto principal:
Encéfalo
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Líquido Cefalorraquidiano
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Líquido Extracelular
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Neurônios
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article