Entry into Lithium Ynolates from α,α,α-Tribromomethyl Ketones: Synthesis of Cyclobutenes via the [2 + 2] Cycloaddition with α,ß-Unsaturated Carbonyls.
Org Lett
; 26(9): 1896-1901, 2024 Mar 08.
Article
em En
| MEDLINE
| ID: mdl-38421178
ABSTRACT
This study reports the synthesis of cyclobutene derivatives in good yields via the [2 + 2] cycloaddition between lithium ynolates and α,ß-unsaturated carbonyls. The ynolates are generated from α,α,α-tribromomethyl ketones and tert-butyl lithium via a simple and novel method, which does not produce any harmful byproducts, such as lithium alkoxide, which induces a polymerization reaction with α,ß-unsaturated carbonyls.
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MEDLINE
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En
Ano de publicação:
2024
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Article