Total Synthesis of (-)-Enigmazole A by the Macrocyclization/Transannular Pyran Cyclization Strategy.
Org Lett
; 26(10): 2045-2050, 2024 Mar 15.
Article
em En
| MEDLINE
| ID: mdl-38421804
ABSTRACT
An 18-step synthesis of (-)-enigmazole A is herein disclosed. The present synthesis is based on a modular assembly of three building blocks of similar complexity, a macrocyclic ring-closing metathesis to forge the 18-membered macrocyclic skeleton, and a desilylative transannular oxa-Michael addition for stereoselective construction of the 2,6-cis-substituted tetrahydropyran ring.
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MEDLINE
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En
Ano de publicação:
2024
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Article