The multivisceral landscape of colorectal cancer metastasis: implications for targeted therapies.
J Clin Invest
; 134(5)2024 Mar 01.
Article
em En
| MEDLINE
| ID: mdl-38426495
ABSTRACT
Colorectal cancer (CRC) is among the most common cancer types and the second deadliest malignancy for both sexes. Metastatic disease poses substantial therapeutic challenges, and peritoneal spread, in particular, reduces quality of life and has a dismal outcome. In this issue of the JCI, Berlin and authors have made considerable advancements in understanding the cellular and molecular composition of multivisceral CRC metastasis in a sophisticated murine orthotopic organoid model and in humans. The study provides unprecedented insights into the complex biology of the disease and points toward the development of compartmentalized immune-therapeutic strategies.
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1
Base de dados:
MEDLINE
Assunto principal:
Qualidade de Vida
/
Neoplasias Colorretais
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article