Restoring Treg/Th17 cell balance in ulcerative colitis through HRas silencing and MAPK pathway inhibition.
Int Immunopharmacol
; 130: 111608, 2024 Mar 30.
Article
em En
| MEDLINE
| ID: mdl-38428143
ABSTRACT
This study investigates HRas-dependent mechanisms in the disruption of regulatory T (Treg) cells and T helper 17 (Th17) cells balance in ulcerative colitis (UC). Comprehensive RNA sequencing and bioinformatics analyses revealed elevated HRas and MAPK pathway-related protein expression in UC samples. Using a murine UC model induced by dextran sulfate sodium (DSS), HRas silencing was found to promote Treg cell differentiation and suppress Th17 cell production, effectively restoring balance. Inactivation of the MAPK pathway played a pivotal role in this rebalancing effect. In vivo experiments further confirmed that HRas silencing mitigated colon tissue damage in DSS-induced mice, emphasizing its potential as a therapeutic strategy for UC.
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Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Colite Ulcerativa
/
Colite
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article