Spiro-Josiphos Ligands for the Ir-Catalyzed Asymmetric Synthesis of Chiral Amines under Hydrogenation Conditions.
Org Lett
; 26(10): 2097-2102, 2024 Mar 15.
Article
em En
| MEDLINE
| ID: mdl-38437523
ABSTRACT
Transition metal-catalyzed asymmetric hydrogenation possesses unparalleled advantages to prepare chiral amines. Here we reported a novel ligand that combined Josiphos and a spirobiindane scaffold and simultaneously investigated its application in Ir-catalyzed asymmetric hydrogenation for the synthesis of chiral amines. Excellent catalytic activity (5000 TON), high enantioselectivity (up to 99% ee), and broad substrate scope (different CâN substrates) make it highly promising for both academic research and industrial applications.
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MEDLINE
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En
Ano de publicação:
2024
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Article