IgA-mediated control of host-microbial interaction during weaning reaction influences gut inflammation.
Gut Microbes
; 16(1): 2323220, 2024.
Article
em En
| MEDLINE
| ID: mdl-38439579
ABSTRACT
The mechanisms of how host-microbe mutualistic relationships are established at weaning contingently upon B-cell surveillance remain inadequately elucidated. We found that CD138+ plasmacyte (PC)-mediated promotion of IgA response regulates the symbiosis between Bacteroides uniformis (B. uniformis) and the host during the weaning period. The IgA-skewed response of CD138+ PCs is essential for B. uniformis to occupy a defined gut luminal niche, thereby fostering stable colonization. Furthermore, B. uniformis within the natural gut niche was perturbed in the absence of IgA, resulting in exacerbated gut inflammation in IgA-deficient mice and weaned piglets. Thus, we propose that the priming and maintenance of intestinal IgA response from CD138+ PCs are required for host-microbial symbiosis, whereas the perturbation of which would enhance inflammation in weaning process.
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Base de dados:
MEDLINE
Assunto principal:
Bacteroides
/
Microbioma Gastrointestinal
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Interações entre Hospedeiro e Microrganismos
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article