[Research progress on the organ-protective effect of Maresin-1 in sepsis].
Zhonghua Wei Zhong Bing Ji Jiu Yi Xue
; 36(2): 211-215, 2024 Feb.
Article
em Zh
| MEDLINE
| ID: mdl-38442942
ABSTRACT
Sepsis is a fatal organ dysfunction caused by the uncontrolled inflammatory response of the host to infection. Excessive inflammatory reaction is the core factor in the occurrence and development of sepsis, the degree of organ dysfunction is directly related to the prognosis of sepsis. Timely intervention of excessive inflammatory response and alleviation of organ function damage are essential to improve the prognosis of sepsis. Maresin-1 (MaR-1) is a newly discovered endogenous specific pro-inflammatory resolution mediator, which plays a role of anti-inflammatory, pro-inflammatory regression and organ protection in sepsis, and may be a new target for the treatment of sepsis. This article reviews the research progress of the role of MaR-1 in the regulation of inflammation and organ protection in sepsis, in order to provide reference for the clinical development of new drugs for the treatment of sepsis.
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MEDLINE
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Sepse
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Insuficiência de Múltiplos Órgãos
Idioma:
Zh
Ano de publicação:
2024
Tipo de documento:
Article