Alanine aminotransferase elevation varies by ethnicity among Asian and Pacific Islander children with overweight or obesity.
Pediatr Obes
; 19(6): e13110, 2024 Jun.
Article
em En
| MEDLINE
| ID: mdl-38444225
ABSTRACT
BACKGROUND:
Limited research on alanine aminotransferase (ALT) screening for metabolic dysfunction-associated steatotic liver disease (MASLD) among US Asian/Pacific Islander (PI) children necessitates investigation in this heterogeneous population.OBJECTIVE:
Examine ALT elevation among Asian/PI children with overweight or obesity.METHODS:
Elevated ALT prevalence (clinical threshold) and association with body mass index ≥85th percentile were compared among 18 402 Asian/PI and 25 376 non-Hispanic White (NHW) children aged 9-17 years using logistic regression.RESULTS:
ALT elevation was more prevalent among Asian/PI (vs. NHW) males with overweight (4.0% vs. 2.7%), moderate (7.8% vs. 5.3%) and severe obesity (16.6% vs. 11.5%), and females with moderate (5.1% vs. 3.0%) and severe obesity (10.2% vs. 5.2%). Adjusted odds of elevated ALT were 1.6-fold and ~2-fold higher for Asian/PI (vs. NHW) males and females (with obesity), respectively. Filipino, Chinese and Southeast Asian males had 1.7-2.1-fold higher odds, but Native Hawaiian/PI (NHPI) and South Asian males did not significantly differ (vs. NHW). Filipina and Chinese females with obesity had >2-fold higher odds, Southeast and South Asian females did not differ and NHPI findings were mixed (vs. NHW).CONCLUSION:
High elevated ALT prevalence among Asian/PI children with overweight and obesity emphasizes the need for MASLD risk assessment and examination of ethnic subgroups.Palavras-chave
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Base de dados:
MEDLINE
Assunto principal:
Havaiano Nativo ou Outro Ilhéu do Pacífico
/
Alanina Transaminase
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Obesidade Infantil
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article