Disease Acceptance, but not Perceived Control, is Uniquely Associated with Inflammatory Bowel Disease-related Disability.
J Crohns Colitis
; 18(7): 1025-1033, 2024 Aug 06.
Article
em En
| MEDLINE
| ID: mdl-38446059
ABSTRACT
BACKGROUND AND AIMS:
Disability, an important aspect of disease burden in patients with inflammatory bowel disease [IBD], has been suggested as a valuable clinical endpoint. We aimed to investigate how disease acceptance and perceived control, two psychological predictors of subjective health, are associated with IBD-related disability.METHODS:
In this cross-sectional study, adult IBD patients from the University Hospitals Leuven received a survey with questions about clinical and demographic characteristics, disease acceptance and perceived control [Subjective Health Experience model questionnaire], and IBD-related disability [IBD Disk]. Multiple linear regressions assessed predictors of IBD-related disability in the total sample and in the subgroups of patients in clinical remission or with active disease.RESULTS:
In the total sample (Nâ =â 1250, 54.2% female, median [interquartile range IQR] age 51 [39-61] years, 61.3% Crohn's disease, 34.9% active disease), adding the psychological predictors to the model resulted in an increased explained variance in IBD-related disability of 19% compared with a model with only demographic and clinical characteristics [R2adj 38% vs 19%, pâ <0.001]. The increase in explained variance was higher for patients in clinical remission [ΔR2adj 20%, pâ <0.001] compared with patients with active disease [ΔR2adj 10%, pâ <0.001]. Of these predictors, disease acceptance was most strongly associated with disability in the total sample [ßâ =â -0.44, pâ <0.001], as well as in both subgroups [ßâ =â -0.47, pâ <0.001 and ßâ =â -0.31, pâ <0.001 respectively]. Perceived control was not significantly associated with disability when accounting for all other predictors.CONCLUSIONS:
Disease acceptance is strongly associated with IBD-related disability, supporting further research into disease acceptance as a treatment target.Palavras-chave
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Base de dados:
MEDLINE
Assunto principal:
Doenças Inflamatórias Intestinais
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article