Your browser doesn't support javascript.
loading
Effectiveness of Dose Increase in Upadacitinib from 15 mg to 30 mg for Patients with Moderate-to-Severe Atopic Dermatitis: A Real-World Clinical Practice in Japan.
Hagino, Teppei; Hamada, Risa; Yoshida, Mai; Saeki, Hidehisa; Fujimoto, Eita; Kanda, Naoko.
Afiliação
  • Hagino T; Department of Dermatology, Nippon Medical School, Chiba Hokusoh Hospital, Kamagari 1715, Inzai, Chiba, 270-1694, Japan. teppei-hagino@nms.ac.jp.
  • Hamada R; Department of Dermatology, Nippon Medical School, Tokyo, Japan.
  • Yoshida M; Department of Dermatology, Nippon Medical School, Tokyo, Japan.
  • Saeki H; Department of Dermatology, Nippon Medical School, Tokyo, Japan.
  • Fujimoto E; Fujimoto Dermatology Clinic, Funabashi, Japan.
  • Kanda N; Department of Dermatology, Nippon Medical School, Chiba Hokusoh Hospital, Kamagari 1715, Inzai, Chiba, 270-1694, Japan.
Clin Drug Investig ; 44(4): 261-269, 2024 Apr.
Article em En | MEDLINE | ID: mdl-38446396
ABSTRACT

BACKGROUND:

Atopic dermatitis is characterized by persistent eczema and pruritus. Janus kinase inhibitors, including upadacitinib, are effective treatments for moderate-to-severe atopic dermatitis. If patients do not respond well to a certain dose of a Janus kinase inhibitor, increasing the dose may improve their treatment responsiveness.

OBJECTIVES:

We assessed the outcomes of a dose increase in upadacitinib from 15 mg to 30 mg for Japanese patients with moderate-to-severe atopic dermatitis.

METHODS:

In 23 patients who showed insufficient responses to upadacitinib 15-mg treatment, the dose of upadacitinib was increased to 30 mg. We evaluated total Eczema Area and Severity Index (EASI), EASI on the head and neck, trunk, upper, or lower limbs, EASI of erythema, edema/papulation, excoriation, or lichenification, and Peak Pruritus Numerical-Rating Scale at baseline (onset of upadactinib 15 mg), week 0 (time of increase), and weeks 4 and 12 after the increase.

RESULTS:

Total EASI, EASI on each anatomical site, EASI of each clinical sign, and Peak Pruritus Numerical-Rating Scale were markedly reduced at weeks 4 or 12 compared with week 0. After the dose increase, the achievement rates of EASI 75 and EASI 90 significantly improved; EASI 75 4.3%, 68.2%, and 66.7%; EASI 90 0%, 18.2%, and 38.1% at weeks 0, 4, and 12, respectively.

CONCLUSIONS:

These results suggest that upadacitinib 30 mg can ameliorate rash and pruritus insufficiently improved by upadacitinib 15 mg, and that the dose increase to 30 mg may be considered as a treatment option for patients with atopic dermatitis with a limited response to upadacitinib 15 mg.
Assuntos

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Dermatite Atópica / Eczema / Inibidores de Janus Quinases / Compostos Heterocíclicos com 3 Anéis Idioma: En Ano de publicação: 2024 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Dermatite Atópica / Eczema / Inibidores de Janus Quinases / Compostos Heterocíclicos com 3 Anéis Idioma: En Ano de publicação: 2024 Tipo de documento: Article