Bioresorbable shape-adaptive structures for ultrasonic monitoring of deep-tissue homeostasis.
Science
; 383(6687): 1096-1103, 2024 Mar 08.
Article
em En
| MEDLINE
| ID: mdl-38452063
ABSTRACT
Monitoring homeostasis is an essential aspect of obtaining pathophysiological insights for treating patients. Accurate, timely assessments of homeostatic dysregulation in deep tissues typically require expensive imaging techniques or invasive biopsies. We introduce a bioresorbable shape-adaptive materials structure that enables real-time monitoring of deep-tissue homeostasis using conventional ultrasound instruments. Collections of small bioresorbable metal disks distributed within thin, pH-responsive hydrogels, deployed by surgical implantation or syringe injection, allow ultrasound-based measurements of spatiotemporal changes in pH for early assessments of anastomotic leaks after gastrointestinal surgeries, and their bioresorption after a recovery period eliminates the need for surgical extraction. Demonstrations in small and large animal models illustrate capabilities in monitoring leakage from the small intestine, the stomach, and the pancreas.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Ultrassom
/
Implantes Absorvíveis
/
Trato Gastrointestinal
/
Fístula Anastomótica
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article