One-pot hydrothermal synthesis of fluorophore-modified cerium oxide nanoparticles.
Phys Chem Chem Phys
; 26(12): 9546-9555, 2024 Mar 20.
Article
em En
| MEDLINE
| ID: mdl-38456314
ABSTRACT
Cerium oxide nanoparticles (CeO2 NPs), which have powerful antioxidant properties, are promising nanomaterials for the treatment of diseases associated with oxidative stress. The well-developed surface of CeO2 NPs makes them promising for use as a multifunctional system for various biomedical applications. This work demonstrates a simple approach that allows the direct formation of a molecular fluorophore on the surface of CeO2 NPs using a simple one-pot hydrothermal synthesis. Thus, we were able to synthesize CeO2 NPs of ultra-small size â¼2 nm with a narrow distribution, highly stable fluorescence, and a quantum yield of â¼62%. UV-visible transmission studies revealed that the resulting CeO2 NPs exhibited fast autogenerative catalytic reduction. In vitro results showed high biocompatibility of CeO2 NPs; their internalization occurs mainly in the region of cell nuclei. Thus, the resulting NPs have the necessary parameters and can be successfully used in biovisualization and therapy.
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MEDLINE
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En
Ano de publicação:
2024
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Article