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IDH-mutant myeloid neoplasms are associated with seronegative rheumatoid arthritis and innate immune activation.
Hong, Lih En; Wechalekar, Mihir D; Kutyna, Monika; Small, Annabelle; Lim, Kelly; Thompson-Peach, Chloe; Li, Joule J; Chhetri, Rakchha; Scott, Hamish S; Brown, Anna; Hahn, Christopher N; Yeung, David T; Sajid, Salvia; Robinson, Nirmal; Thomas, Ranjeny; Branford, Susan; D'Andrea, Richard J; Samaraweera, Saumya E; Patnaik, Mrinal; Proudman, Susanna; Thomas, Daniel; Kok, Chung Hoow; Shah, Mithun V; Hiwase, Devendra K.
Afiliação
  • Hong LE; Rheumatology Unit, Royal Adelaide Hospital, Adelaide, Australia.
  • Wechalekar MD; Adelaide Medical School, University of Adelaide, Adelaide, Australia.
  • Kutyna M; Rheumatology Unit, Royal Adelaide Hospital, Adelaide, Australia.
  • Small A; Rheumatology Unit, Flinders Medical Centre, Adelaide, Australia.
  • Lim K; College of Medicine and Public Health, Flinders University, Adelaide, Australia.
  • Thompson-Peach C; Haematology Department, Central Adelaide Local Health Network, Adelaide, Australia.
  • Li JJ; Blood Cancer, Precision Medicine Theme, South Australian Health and Medical Research Institute, Adelaide, Australia.
  • Chhetri R; College of Medicine and Public Health, Flinders University, Adelaide, Australia.
  • Scott HS; Adelaide Medical School, University of Adelaide, Adelaide, Australia.
  • Brown A; Blood Cancer, Precision Medicine Theme, South Australian Health and Medical Research Institute, Adelaide, Australia.
  • Hahn CN; Adelaide Medical School, University of Adelaide, Adelaide, Australia.
  • Yeung DT; Blood Cancer, Precision Medicine Theme, South Australian Health and Medical Research Institute, Adelaide, Australia.
  • Sajid S; Haematology Department, Central Adelaide Local Health Network, Adelaide, Australia.
  • Robinson N; Adelaide Medical School, University of Adelaide, Adelaide, Australia.
  • Thomas R; Haematology Department, Central Adelaide Local Health Network, Adelaide, Australia.
  • Branford S; Adelaide Medical School, University of Adelaide, Adelaide, Australia.
  • D'Andrea RJ; Centre for Cancer Biology, SA Pathology and University of South Australia, Adelaide, Australia.
  • Samaraweera SE; Genetics and Molecular Pathology, SA Pathology, Adelaide, Australia.
  • Patnaik M; Adelaide Medical School, University of Adelaide, Adelaide, Australia.
  • Proudman S; Centre for Cancer Biology, SA Pathology and University of South Australia, Adelaide, Australia.
  • Thomas D; Genetics and Molecular Pathology, SA Pathology, Adelaide, Australia.
  • Kok CH; Adelaide Medical School, University of Adelaide, Adelaide, Australia.
  • Shah MV; Centre for Cancer Biology, SA Pathology and University of South Australia, Adelaide, Australia.
  • Hiwase DK; Genetics and Molecular Pathology, SA Pathology, Adelaide, Australia.
Blood ; 143(18): 1873-1877, 2024 May 02.
Article em En | MEDLINE | ID: mdl-38457663
ABSTRACT
ABSTRACT High prevalence of IDH mutations in seronegative rheumatoid arthritis (RA) with myeloid neoplasm, elevated 2-hydroxyglutarate, dysregulated innate immunity, and proinflammatory microenvironment suggests causative association between IDH mutations and seronegative RA. Our findings merit investigation of IDH inhibitors as therapeutics for seronegative IDH-mutated RA.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Artrite Reumatoide / Imunidade Inata / Isocitrato Desidrogenase / Mutação Idioma: En Ano de publicação: 2024 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Artrite Reumatoide / Imunidade Inata / Isocitrato Desidrogenase / Mutação Idioma: En Ano de publicação: 2024 Tipo de documento: Article