Chromones from the endophytic fungus Bipolaris eleusines.
Phytochemistry
; 221: 114046, 2024 May.
Article
em En
| MEDLINE
| ID: mdl-38460780
ABSTRACT
Eight previously undescribed chromones eleusineketones A-H (1-8), as well as eight known compounds (9-16), were isolated from the endophytic fungus Bipolaris eleusines. These planar structures were created using an in-depth analysis of their spectral data, which included 1D, 2D, and HRESIMS data. Furthermore, the absolute configurations of compounds 1, 2, and 6 were determined by spectroscopic analysis and quantum chemical computational approaches, and compound 5 was determined by single-crystal X-ray diffraction analysis. The cytotoxic activity assay revealed that compounds 1 and 5 both inhibited MDA-MB-231 cells with IC50 values of 14.48 µM and 17.99 µM, respectively.
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Base de dados:
MEDLINE
Assunto principal:
Ascomicetos
/
Cromonas
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article