Association of Vitamin D Levels with Risk of Cognitive Impairment and Dementia: A Systematic Review and Meta-Analysis of Prospective Studies.
J Alzheimers Dis
; 98(2): 373-385, 2024.
Article
em En
| MEDLINE
| ID: mdl-38461506
ABSTRACT
Background:
Emerging evidence suggests the potential relationship between vitamin D deficiency and risk of cognitive impairment or dementia. To what extent the excess risk of dementia conferred by vitamin D deficiency is less clear.Objective:
We summarized the current evidence from several aspects and further quantified these associations.Methods:
We collected relevant prospective cohort studies by searching PubMed, Embase and Cochrane up to July 2023. The pooled relative risks (RR) were evaluated by random-effects models. Dose-response analyses were conducted by the method of two-stage generalized least squares regression.Results:
Of 9,267 identified literatures, 23 were eligible for inclusion in the meta-analyses, among which 9 and 4 literatures were included in the dose-response analyses for the risk of dementia and Alzheimer's disease (AD). Vitamin D deficiency exhibited a 1.42 times risk for dementia (95% confidence interval (CI)â=â1.21-1.65) and a 1.57-fold excess risk for AD (95% CIâ=â1.15-2.14). And vitamin D deficiency was associated with 34% elevated risk with cognitive impairment (95% CIâ=â1.19-1.52). Additionally, vitamin D was non-linearly related to the risk of dementia (pnonlinearityâ=â0.0000) and AD (pnonlinearityâ=â0.0042). The approximate 77.5-100ânmol/L 25-hydroxyvitamin D [25(OH)D] was optimal for reducing dementia risk. And the AD risk seemed to be decreased when the 25(OH)D level >40.1ânmol/L.Conclusions:
Vitamin D deficiency was a risk factor for dementia, AD, and cognitive impairment. The nonlinear relationships may further provide the optimum dose of 25(OH)D for dementia prevention.Palavras-chave
Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Vitamina D
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Deficiência de Vitamina D
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Demência
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Disfunção Cognitiva
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article