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Pretreatment and Acquired Drug Resistance in Children With Human Immunodeficiency Virus Type 1 in Jos, Nigeria.
Ebonyi, Augustine O; Okpokwu, Jonathan; Rawizza, Holly; Chebu, Philippe; Chaplin, Beth; Hamel, Donald; Oguche, Stephen; Agbaji, Oche O; Sagay, Atiene S; Kanki, Phyllis J; Imade, Godwin E.
Afiliação
  • Ebonyi AO; Department of Paediatrics, University of Jos, Jos University Teaching Hospital, Jos, Nigeria.
  • Okpokwu J; AIDS Prevention Initiative in Nigeria-supported ISO 15189 Laboratory, Jos University Teaching Hospital, Jos, Nigeria.
  • Rawizza H; Department of Immunology and Infectious Diseases, Harvard T. H. Chan School of Public Health, Boston, Massachusetts, USA.
  • Chebu P; APIN Public Health Initiatives, Plot 1551, Apo Resettlement, Apo District, Abuja, FCT, Nigeria.
  • Chaplin B; Department of Immunology and Infectious Diseases, Harvard T. H. Chan School of Public Health, Boston, Massachusetts, USA.
  • Hamel D; Department of Immunology and Infectious Diseases, Harvard T. H. Chan School of Public Health, Boston, Massachusetts, USA.
  • Oguche S; Department of Paediatrics, University of Jos, Jos University Teaching Hospital, Jos, Nigeria.
  • Agbaji OO; Department of Medicine, University of Jos, Jos University Teaching Hospital, Jos, Nigeria.
  • Sagay AS; Department of Obstetrics and Gynaecology, University of Jos, Jos University Teaching Hospital, Jos, Nigeria.
  • Kanki PJ; Department of Immunology and Infectious Diseases, Harvard T. H. Chan School of Public Health, Boston, Massachusetts, USA.
  • Imade GE; AIDS Prevention Initiative in Nigeria-supported ISO 15189 Laboratory, Jos University Teaching Hospital, Jos, Nigeria.
Open Forum Infect Dis ; 11(3): ofae092, 2024 Mar.
Article em En | MEDLINE | ID: mdl-38464491
ABSTRACT
We determined pretreatment and acquired human immunodeficiency virus (HIV) drug resistance among children with HIV type 1 (HIV-1) in Jos, Nigeria. The majority (71%) of those who failed first-line antiretroviral therapy were on a nevirapine-containing regimen. The prevalence of pretreatment (48%) and acquired (76%) HIV drug resistance mutations was high in our study. Wider access to HIV drug resistance testing after treatment failure is necessary to optimize second-line treatment options among children with HIV in Nigeria.
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Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2024 Tipo de documento: Article
Texto completo
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PubMed Links
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Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2024 Tipo de documento: Article