FUT4 promotes the progression of Cholangiocarcinoma by modulating epithelial-mesenchymal transition.
Cell Cycle
; 23(2): 218-231, 2024 Jan.
Article
em En
| MEDLINE
| ID: mdl-38466946
ABSTRACT
Cholangiocarcinoma (CCA) is a common gastrointestinal malignancy characterized by a poor prognosis. Considering its prevalence, exploring its underlying molecular biological mechanisms is of paramount clinical importance. In this study, bioinformatics techniques were utilized to analyze CCA sample data obtained from The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) databases. The analysis revealed a notable upregulation in FUT4 expression in CCA samples. To further investigate the functional implications of FUT4, in vivo and in vitro experiments were conducted, which demonstrated that FUT4 overexpression significantly enhances the proliferative and migratory capabilities of tumor cells. Subsequent sequencing analysis unveiled a correlation between FUT4 and epithelial-mesenchymal transition (EMT). Indeed, the pioneering discovery of elevated FUT4 expression in CCA was highlighted in this study. Further investigations into the function of FUT4 in CCA provided initial insights into its role in driving cancer progression via EMT. These findings present promising avenues for the diagnosis and treatment of CCA.[Figure see text].
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Base de dados:
MEDLINE
Assunto principal:
Neoplasias dos Ductos Biliares
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Regulação Neoplásica da Expressão Gênica
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Movimento Celular
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Colangiocarcinoma
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Progressão da Doença
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Proliferação de Células
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Transição Epitelial-Mesenquimal
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Fucosiltransferases
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article