A visible-light-induced photosensitizer-free decarbonylative Minisci-type reaction.
Org Biomol Chem
; 22(13): 2654-2661, 2024 Mar 27.
Article
em En
| MEDLINE
| ID: mdl-38470359
ABSTRACT
This study presents a green and practical visible-light-induced photosensitizer-free decarbonylative Minisci-type reaction using aldehydes as alkyl radical precursors. The photocatalytic system exhibits a broad substrate scope and synthetically useful yields. Mechanistic experiments revealed that alkyl radicals could be generated through auto-oxidation of aldehydes under irradiation, which is a mild and effective method for achieving late-stage functionalization of N-heteroarenes. Some biologically active N-heteroarenes could be alkylated using this photocatalytic system smoothly.
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MEDLINE
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En
Ano de publicação:
2024
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Article