Lower Rates of Hypocalcemia Following Near-Infrared Autofluorescence Use in Thyroidectomy: A Meta-Analysis of RCTs.

Rao, Karthik N; Rajguru, Renu; Dange, Prajwal; Vetter, Diana; Triponez, Frederic; Nixon, Iain J; Randolph, Gregory W; Mäkitie, Antti A; Zafereo, Mark; Ferlito, Alfio

Rao, Karthik N; Rajguru, Renu; Dange, Prajwal; Vetter, Diana; Triponez, Frederic; Nixon, Iain J; Randolph, Gregory W; Mäkitie, Antti A; Zafereo, Mark; Ferlito, Alfio.

Afiliação

Rao KN; Department of Head and Neck Oncology, All India Institute of Medical Sciences, Raipur 492099, India.
Rajguru R; Sri Shankara Cancer Hospital and Research Center, Bangalore 560004, India.
Dange P; Department of Otorhinolaryngology and Head Neck Surgery, All India Institute of Medical Sciences, Raipur 492099, India.
Vetter D; Department of Head and Neck Oncology, All India Institute of Medical Sciences, Raipur 492099, India.
Triponez F; Department of Visceral and Transplant Surgery, University Hospital Zurich, 8032 Zurich, Switzerland.
Nixon IJ; Department of Thoracic and Endocrine Surgery, University Hospitals of Geneva, 1205 Geneva, Switzerland.
Randolph GW; Department of Surgery and Otolaryngology, Head and Neck Surgery, Edinburgh University, Edinburgh EH3 9YL, UK.
Mäkitie AA; Division of Thyroid and Parathyroid Endocrine Surgery, Department of Otolaryngology-Head and Neck Surgery, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, MA 02114, USA.
Zafereo M; Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.
Ferlito A; Department of Otorhinolaryngology, Head and Neck Surgery, Research Program in Systems Oncology, Faculty of Medicine, University of Helsinki, Helsinki University Hospital, 00014 Helsinki, Finland.

Diagnostics (Basel) ; 14(5)2024 Feb 27.

Article em En | MEDLINE | ID: mdl-38472977

ABSTRACT

ABSTRACT

BACKGROUND:

Iatrogenic injury of the parathyroid glands is the most frequent complication after total thyroidectomy.

OBJECTIVE:

To determine the effectiveness of near-infrared autofluorescence (NIRAF) in reducing postoperative hypocalcemia following total thyroidectomy.

METHODS:

PubMed, Scopus, and Google Scholar databases were searched. Randomised trials reporting at least one hypocalcemia outcome following total thyroidectomy using NIRAF were included.

RESULTS:

The qualitative data synthesis comprised 1363 patients from nine randomised studies, NIRAF arm = 636 cases and non-NIRAF arm = 637 cases. There was a statistically significant difference in the overall rate of hypocalcemia log(OR) = -0.7 [(-1.01, -0.40), M-H, REM, CI = 95%] and temporary hypocalcemia log(OR) = -0.8 [(-1.01, -0.59), M-H, REM, CI = 95%] favouring the NIRAF. The difference in the rate of permanent hypocalcemia log(OR) = -1.09 [(-2.34, 0.17), M-H, REM, CI = 95%] between the two arms was lower in the NIRAF arm but was not statistically significant.