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The one-carbon metabolism as an underlying pathway for placental DNA methylation - a systematic review.
van Vliet, Marjolein M; Schoenmakers, Sam; Gribnau, Joost; Steegers-Theunissen, Régine P M.
Afiliação
  • van Vliet MM; Department of Obstetrics and Gynaecology, Erasmus MC, Rotterdam, the Netherlands.
  • Schoenmakers S; Department of Developmental Biology, Erasmus MC, Rotterdam, the Netherlands.
  • Gribnau J; Department of Obstetrics and Gynaecology, Erasmus MC, Rotterdam, the Netherlands.
  • Steegers-Theunissen RPM; Department of Developmental Biology, Erasmus MC, Rotterdam, the Netherlands.
Epigenetics ; 19(1): 2318516, 2024 Dec.
Article em En | MEDLINE | ID: mdl-38484284
ABSTRACT
Epigenetic modifications, including DNA methylation, are proposed mechanisms explaining the impact of parental exposures to foetal development and lifelong health. Micronutrients including folate, choline, and vitamin B12 provide methyl groups for the one-carbon metabolism and subsequent DNA methylation processes. Placental DNA methylation changes in response to one-carbon moieties hold potential targets to improve obstetrical care. We conducted a systematic review on the associations between one-carbon metabolism and human placental DNA methylation. We included 22 studies. Findings from clinical studies with minimal ErasmusAGE quality score 5/10 (n = 15) and in vitro studies (n = 3) are summarized for different one-carbon moieties. Next, results are discussed per study

approach:

(1) global DNA methylation (n = 9), (2) genome-wide analyses (n = 4), and (3) gene specific (n = 14). Generally, one-carbon moieties were not associated with global methylation, although conflicting outcomes were reported specifically for choline. Using genome-wide approaches, few differentially methylated sites associated with S-adenosylmethionine (SAM), S-adenosylhomocysteine (SAH), or dietary patterns. Most studies taking a gene-specific approach indicated site-specific relationships depending on studied moiety and genomic region, specifically in genes involved in growth and development including LEP, NR3C1, CRH, and PlGF; however, overlap between studies was low. Therefore, we recommend to further investigate the impact of an optimized one-carbon metabolism on DNA methylation and lifelong health.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Placenta / Metilação de DNA Idioma: En Ano de publicação: 2024 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Placenta / Metilação de DNA Idioma: En Ano de publicação: 2024 Tipo de documento: Article