The Use of a Novel Donkey Milk-Derived Human Milk Fortified in the Neonatal Period Had No Effect on the Frequency of Allergic Manifestations During the First Years of Life: The "Fortilat Trial" Follow-Up.
Breastfeed Med
; 19(3): 223-227, 2024 Mar.
Article
em En
| MEDLINE
| ID: mdl-38489532
ABSTRACT
Background:
Since human milk contents does not meet the high need of very low birth weight infants, fortification of breast milk is a standard practice for this population. As donkey milk has been long considered for children allergic to cow's milk proteins due to its low allergic properties, a new donkey milk-derived fortifier (DF) has been recently evaluated as a valid alternative to bovine milk-derived fortifier (BF). It seems to improve feeding tolerance when compared with standard BF, with similar neurodevelopmental and auxological outcome at 18 months of age. The aim of this study is to evaluate the development of allergic manifestations occurring in the population of the "Fortilat Trial" at 6-8 years of age.Methods:
Allergic manifestations were assessed by an ad hoc questionnaire administered to families. The occurrence of asthma, allergic rhinitis and oculorhinitis, rashes and atopic dermatitis, food allergies, accesses to an emergency department for allergic reactions, and the need of antihistamine have been investigated.Results:
In total, 113 infants were enrolled in the study (BF arm n = 60, DF arm n = 53). No difference in risk was observed between the two groups for all the considered outcomes. In conclusion, our data suggest that DF does not impact the development of allergic manifestations in the first years of life. Clinical Trial Registration number ISRCT N70022881.Palavras-chave
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Base de dados:
MEDLINE
Assunto principal:
Hipersensibilidade a Leite
/
Hipersensibilidade Alimentar
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article