Emerging Role of Fibroblasts in Vitiligo: A Formerly Underestimated Rising Star.
J Invest Dermatol
; 144(8): 1696-1706, 2024 Aug.
Article
em En
| MEDLINE
| ID: mdl-38493384
ABSTRACT
Vitiligo is a disfiguring depigmentation disorder characterized by loss of melanocytes. Although numerous studies have been conducted on the pathogenesis of vitiligo, the underlying mechanisms remain unclear. Although most studies have focused on melanocytes and keratinocytes, growing evidence suggests the involvement of dermal fibroblasts, residing deeper in the skin. This review aims to elucidate the role of fibroblasts in both the physiological regulation of skin pigmentation and their pathological contribution to depigmentation, with the goal of shedding light on the involvement of fibroblasts in vitiligo. The topics covered in this review include alterations in the secretome, premature senescence, autophagy dysfunction, abnormal extracellular matrix, autoimmunity, and metabolic changes.
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Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Vitiligo
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Fibroblastos
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Melanócitos
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article