Protein phosphorylation and kinases: Potential therapeutic targets in necroptosis.
Eur J Pharmacol
; 970: 176508, 2024 May 05.
Article
em En
| MEDLINE
| ID: mdl-38493913
ABSTRACT
Necroptosis is a pivotal contributor to the pathogenesis of various human diseases, including those affecting the nervous system, cardiovascular system, pulmonary system, and kidneys. Extensive investigations have elucidated the mechanisms and physiological ramifications of necroptosis. Among these, protein phosphorylation emerges as a paramount regulatory process, facilitating the activation or inhibition of specific proteins through the addition of phosphate groups to their corresponding amino acid residues. Currently, the targeting of kinases has gained recognition as a firmly established and efficacious therapeutic approach for diverse diseases, notably cancer. In this comprehensive review, we elucidate the intricate role of phosphorylation in governing key molecular players in the necroptotic pathway. Moreover, we provide an in-depth analysis of recent advancements in the development of kinase inhibitors aimed at modulating necroptosis. Lastly, we deliberate on the prospects and challenges associated with the utilization of kinase inhibitors to modulate necroptotic processes.
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Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Proteínas Quinases
/
Neoplasias
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article