Major adverse events in youth-onset type 1 and type 2 diabetes: The SEARCH and TODAY studies.
Diabetes Res Clin Pract
; 210: 111606, 2024 Apr.
Article
em En
| MEDLINE
| ID: mdl-38493952
ABSTRACT
AIMS:
To determine contemporary incidence rates and risk factors for major adverse events in youth-onset T1D and T2D.METHODS:
Participant interviews were conducted once during in-person visits from 2018 to 2019 in SEARCH (T1D N = 564; T2D N = 149) and semi-annually from 2014 to 2020 in TODAY (T2D N = 495). Outcomes were adjudicated using harmonized, predetermined, standardized criteria.RESULTS:
Incidence rates (events per 10,000 person-years) among T1D participants were 10.9 ophthalmologic; 0 kidney; 11.1 nerve, 3.1 cardiac; 3.1 peripheral vascular; 1.6 cerebrovascular; and 15.6 gastrointestinal events. Among T2D participants, rates were 40.0 ophthalmologic; 6.2 kidney; 21.2 nerve; 21.2 cardiac; 10.0 peripheral vascular; 5.0 cerebrovascular and 42.8 gastrointestinal events. Despite similar mean diabetes duration, complications were higher in youth with T2D than T1D 2.5-fold higher for microvascular, 4.0-fold higher for macrovascular, and 2.7-fold higher for gastrointestinal disease. Univariate logistic regression analyses in T1D associated age at diagnosis, female sex, HbA1c and mean arterial pressure (MAP) with microvascular events. In youth-onset T2D, composite microvascular events associated positively with MAP and negatively with BMI, however composite macrovascular events associated solely with MAP.CONCLUSIONS:
In youth-onset diabetes, end-organ events were infrequent but did occur before 15 years diabetes duration. Rates were higher and had different risk factors in T2D versus T1D.Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Diabetes Mellitus Tipo 1
/
Diabetes Mellitus Tipo 2
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article