Crosstalk between TPC2 and IP<sub>3</sub>R regulates Ca<sup>2+</sup> signals.

Humer, Christina; Schindl, Rainer; Sallinger, Matthias

Crosstalk between TPC2 and IP₃R regulates Ca²⁺ signals.

Humer, Christina; Schindl, Rainer; Sallinger, Matthias.

Afiliação

Humer C; Institute of Biophysics, Johannes Kepler University Linz, Linz, Austria.
Schindl R; Department of Medical Physics and Biophysics, Medical University of Graz, Graz, Austria. Electronic address: rainer.schindl@medunigraz.at.
Sallinger M; Institute of Biophysics, Johannes Kepler University Linz, Linz, Austria.

Trends Cell Biol ; 34(5): 352-354, 2024 May.

Article em En | MEDLINE | ID: mdl-38494377

ABSTRACT

ABSTRACT

Calcium (Ca2+) plays a pivotal role in cellular signal transmission by triggering downstream signaling in response to an increase in the cytosolic Ca2+ concentration. Intracellular organelles serve as Ca2+ stores that induce differently shaped Ca2+ signals. We discuss a study by Yuan et al. that investigated the interplay between the lysosomal two-pore channel 2 (TPC2) and endoplasmic reticulum (ER)-localized inositol 1,4,5-trisphosphate receptors (IP3Rs).

Assuntos

Canais de Cálcio; Sinalização do Cálcio; Receptores de Inositol 1,4,5-Trifosfato; Receptores de Inositol 1,4,5-Trifosfato/metabolismo; Humanos; Animais; Canais de Cálcio/metabolismo; Cálcio/metabolismo; Retículo Endoplasmático/metabolismo; Lisossomos/metabolismo

Palavras-chave

IP3R; MITF; TFEB; TPC2; lysosomal Ca(2+)

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Canais de Cálcio / Sinalização do Cálcio / Receptores de Inositol 1,4,5-Trifosfato Idioma: En Ano de publicação: 2024 Tipo de documento: Article

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