Inter-claudin antagonism of paracellular pore function: mechanism and beyond.
Tissue Barriers
; : 2330773, 2024 Mar 17.
Article
em En
| MEDLINE
| ID: mdl-38494648
ABSTRACT
Claudin-2-dependent pore function mediates paracellular cation permeability and can result in pathogenesis of many diseases. Although existing various types of claudins, including barrier-forming and pore-forming claudins, their heterodimeric interaction affecting barrier and pore functions has never been fully elucidated yet. Recently, Shashikanth and colleagues demonstrated that expression of claudin-4 was able to antagonize paracellular pore activity of claudin-2. This commentary will emphasize the mechanism underlying claudin-4-mediated claudin-2-dependent pore inhibition and discuss its potential therapeutic and prognostic applications.
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MEDLINE
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En
Ano de publicação:
2024
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Article