Early vs. delayed mechanical circulatory support in patients with acute myocardial infarction and cardiogenic shock.
Eur Heart J Acute Cardiovasc Care
; 13(5): 390-397, 2024 May 28.
Article
em En
| MEDLINE
| ID: mdl-38502888
ABSTRACT
AIMS:
Despite increased temporary mechanical circulatory support (tMCS) utilization for acute myocardial infarction complicated by cardiogenic shock (AMI-CS), data regarding efficacy and optimal timing for tMCS support are limited. This study aimed to describe outcomes based on tMCS timing in AMI-CS and to identify predictors of 30-day mortality and readmission. METHODS ANDRESULTS:
Patients with AMI-CS identified in the National Readmissions Database were grouped according to the use of tMCS and early (<24â h) vs. delayed (≥24â h) tMCS. The correlation between tMCS timing and inpatient outcomes was evaluated using linear regression. Multivariate logistic regression was used to identify variables associated with 30-day mortality and readmission. Of 294 839 patients with AMI-CS, 109 148 patients were supported with tMCS (8067 veno-arterial extracorporeal membrane oxygenation, 33 577 Impella, and 79 161 intra-aortic balloon pump). Of patients requiring tMCS, patients who received early tMCS (n = 79 906) had shorter lengths of stay (7 vs. 15 days, P < 0.001) and lower rates of ischaemic and bleeding complications than those with delayed tMCS (n = 32 241). Patients requiring tMCS had higher in-hospital mortality [odds ratio (95% confidence interval)] [1.7 (1.7-1.8), P < 0.001]. Among patients requiring tMCS, early support was associated with fewer complications, lower mortality [0.90 (0.85-0.94), P < 0.001], and fewer 30-day readmissions [0.91 (0.85-0.97), P = 0.005] compared with patients with delayed tMCS.CONCLUSION:
Among patients receiving tMCS for AMI-CS, early tMCS was associated with fewer complications, shorter lengths of stay, lower hospital costs, and fewer deaths and readmissions at 30 days.Palavras-chave
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Base de dados:
MEDLINE
Assunto principal:
Choque Cardiogênico
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Oxigenação por Membrana Extracorpórea
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Coração Auxiliar
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Mortalidade Hospitalar
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Balão Intra-Aórtico
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Infarto do Miocárdio
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article