The contribution of vitamin D insufficiency to the onset of steatotic liver disease among individuals with metabolic dysfunction.
Sci Rep
; 14(1): 6714, 2024 03 20.
Article
em En
| MEDLINE
| ID: mdl-38509247
ABSTRACT
The interplay between fatty liver disease (FLD) and metabolic dysfunction has given rise to the concept of metabolic associated fatty liver disease (MAFLD). With vitamin D insufficiency frequently co-occurring with FLD and linked to metabolic abnormalities, this study investigates the potential role of vitamin D in the development of MAFLD. In this cross-sectional analysis, 22,476 participants with baseline metabolic dysfunction and known serum 25-OH-vitamin D3 levels were examined. The fatty liver index (FLI) was utilized to predict FLD, dividing subjects into MAFLD and non-MAFLD groups. Further stratification by vitamin D levels (sufficient vs. insufficient) and gender provided a detailed assessment through binary logistic regression to determine the association of vitamin D status with MAFLD incidence. Vitamin D insufficiency correlated with a higher MAFLD incidence in metabolically impaired individuals. Post-adjustment, the correlation was stronger (men aOR = 1.32, 95% CI = 1.22-1.43, P < 0.001; women aOR = 1.53, 95% CI = 1.18-1.98, P = 0.001). Lower serum 25-OH-vitamin D3 levels were found in MAFLD patients across genders (men P = 0.003; women P = 0.014), with a higher prevalence of insufficiency in MAFLD cases (men P = 0.007; women P = 0.003). The vitamin D-MAFLD link was stable across subgroups and using varying FLI criteria. Our findings indicate a clear association between vitamin D insufficiency and increased MAFLD incidence, underscoring the potential of vitamin D as an anti-lipogenic and anti-fibrotic agent.
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Base de dados:
MEDLINE
Assunto principal:
Deficiência de Vitamina D
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Hepatopatia Gordurosa não Alcoólica
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article