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Fatigue-Related Changes of Daily Function: Most Promising Measures for the Digital Age.
Maetzler, Walter; Correia Guedes, Leonor; Emmert, Kirsten Nele; Kudelka, Jennifer; Hildesheim, Hanna Luise; Paulides, Emma; Connolly, Hayley; Davies, Kristen; Dilda, Valentina; Ahmaniemi, Teemu; Avedano, Luisa; Bouça-Machado, Raquel; Chambers, Michael; Chatterjee, Meenakshi; Gallagher, Peter; Graeber, Johanna; Maetzler, Corina; Kaduszkiewicz, Hanna; Kennedy, Norelee; Macrae, Victoria; Carrasco Marin, Laura; Moses, Anusha; Padovani, Alessandro; Pilotto, Andrea; Ratcliffe, Natasha; Reilmann, Ralf; Rosario, Madalena; Schreiber, Stefan; De Sousa, Dina; Van Gassen, Geert; Warring, Lori Ann; Seppi, Klaus; van der Woude, C Janneke; Ferreira, Joaquim J; Ng, Wan-Fai.
Afiliação
  • Maetzler W; Department of Neurology, University Medical Centre Schleswig-Holstein, Campus Kiel and Kiel University, Kiel, Germany.
  • Correia Guedes L; Instituto de Medicina Molecular João Lobo Antunes and Centro de Estudos Egas Moniz, Faculdade de Medicina da Universidade de Lisboa, Lisbon, Portugal.
  • Emmert KN; Department of Neurology, University Medical Centre Schleswig-Holstein, Campus Kiel and Kiel University, Kiel, Germany.
  • Kudelka J; Department of Neurology, University Medical Centre Schleswig-Holstein, Campus Kiel and Kiel University, Kiel, Germany.
  • Hildesheim HL; Department of Neurology, University Medical Centre Schleswig-Holstein, Campus Kiel and Kiel University, Kiel, Germany.
  • Paulides E; Department of Gastroenterology and Hepatology, Erasmus University Medical Centre, Rotterdam, The Netherlands.
  • Connolly H; School of Allied Health, Faculty of Education and Health Sciences and Health Research Institute, University of Limerick, Limerick, Ireland.
  • Davies K; Translational and Clinical Research Institute, Newcastle University and NIHR Newcastle Biomedical Research Centre, Newcastle upon Tyne, UK.
  • Dilda V; CHDI Management, CHDI Foundation, Princeton, NJ, USA.
  • Ahmaniemi T; Teknologian tutkimuskeskus VTT Oy, Espoo, Finland.
  • Avedano L; European Federation of Crohn's and Ulcerative Colitis, Brussels, Belgium.
  • Bouça-Machado R; Instituto de Medicina Molecular João Lobo Antunes and Centro de Estudos Egas Moniz, Faculdade de Medicina da Universidade de Lisboa, Lisbon, Portugal.
  • Chambers M; MC Healthcare Evaluation, London, UK.
  • Chatterjee M; Janssen Research and Development, Cambridge, MA, USA.
  • Gallagher P; Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, UK.
  • Graeber J; Institute of General Medicine, University Medical Centre Schleswig-Holstein, Kiel University, Kiel, Germany.
  • Maetzler C; Department of Neurology, University Medical Centre Schleswig-Holstein, Campus Kiel and Kiel University, Kiel, Germany.
  • Kaduszkiewicz H; Institute of General Medicine, University Medical Centre Schleswig-Holstein, Kiel University, Kiel, Germany.
  • Kennedy N; School of Allied Health, Faculty of Education and Health Sciences and Health Research Institute, University of Limerick, Limerick, Ireland.
  • Macrae V; Translational and Clinical Research Institute, Newcastle University and NIHR Newcastle Biomedical Research Centre, Newcastle upon Tyne, UK.
  • Carrasco Marin L; Asociación Parkinson Madrid, Madrid, Spain.
  • Moses A; School of Allied Health, Faculty of Education and Health Sciences and Health Research Institute, University of Limerick, Limerick, Ireland.
  • Padovani A; University of Twente, Department of Medical Cell Biophysics, TechMed Centre, Enschede, The Netherlands.
  • Pilotto A; Neurology Unit, Department of Clinical and Experimental Sciences, University of Brescia, Brescia, Italy.
  • Ratcliffe N; Neurology Unit, Department of Clinical and Experimental Sciences, University of Brescia, Brescia, Italy.
  • Reilmann R; Parkinson's UK, London, UK.
  • Rosario M; George-Huntington-Institute, R&D-Campus/Technology-Park Münster, Münster, Germany.
  • Schreiber S; Institute of Clinical Radiology, University of Münster, Münster, Germany.
  • De Sousa D; Department of Neurodegeneration, Hertie Institute for Clinical Brain Research, University of Tübingen, Tübingen, Germany.
  • Van Gassen G; Instituto de Medicina Molecular João Lobo Antunes and Centro de Estudos Egas Moniz, Faculdade de Medicina da Universidade de Lisboa, Lisbon, Portugal.
  • Warring LA; Department of Internal Medicine I, University Medical Centre Schleswig-Holstein, Kiel University, Kiel, Germany.
  • Seppi K; European Huntington's Association, Moerbeke, Belgium.
  • van der Woude CJ; Medical Department, Takeda, Brussels, Belgium.
  • Ferreira JJ; Janssen LLC, GCSO Immunology, Horsham, PA, USA.
  • Ng WF; Department of Neurology, Medical University Innsbruck, Innsbruck, Austria.
Digit Biomark ; 8(1): 30-39, 2024.
Article em En | MEDLINE | ID: mdl-38510264
ABSTRACT

Background:

Fatigue is a prominent symptom in many diseases and is strongly associated with impaired daily function. The measurement of daily function is currently almost always done with questionnaires, which are subjective and imprecise. With the recent advances of digital wearable technologies, novel approaches to evaluate daily function quantitatively and objectively in real-life conditions are increasingly possible. This also creates new possibilities to measure fatigue-related changes of daily function using such technologies.

Summary:

This review examines which digitally assessable parameters in immune-mediated inflammatory and neurodegenerative diseases may have the greatest potential to reflect fatigue-related changes of daily function. Key Messages Results of a standardized analysis of the literature reporting about perception-, capacity-, and performance-evaluating assessment tools indicate that changes of the following parameters physical activity, independence of daily living, social participation, working life, mental status, cognitive and aerobic capacity, and supervised and unsupervised mobility performance have the highest potential to reflect fatigue-related changes of daily function. These parameters thus hold the greatest potential for quantitatively measuring fatigue in representative diseases in real-life conditions, e.g., with digital wearable technologies. Furthermore, to the best of our knowledge, this is a new approach to analysing evidence for the design of performance-based digital assessment protocols in human research, which may stimulate further systematic research in this area.
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Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2024 Tipo de documento: Article
Texto completo
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XML
PubMed Links
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Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2024 Tipo de documento: Article