[Research progress on the role of hepatitis B virus DNA integration in chronic hepatitis B].
Zhonghua Gan Zang Bing Za Zhi
; 32(2): 164-167, 2024 Feb 20.
Article
em Zh
| MEDLINE
| ID: mdl-38514268
ABSTRACT
Chronic hepatitis B virus (HBV) infection will greatly contribute to raising the occurrence probability of cirrhosis and hepatocellular carcinoma in patients. Although existing antiviral treatment regimens have a certain effect on delaying disease progression and improving prognosis, it is still not effective in attaining functional cures. Hepatitis B virus DNA integration may be one of the reasons for this phenomenon. Therefore, this paper reviews the possible mechanisms of HBV DNA integration in maintaining chronic inflammation of the liver, evading existing antiviral treatment methods, and inducing hepatocellular carcinoma so as to further deepen the understanding of the role of HBV DNA integration in the occurrence and development of chronic hepatitis B, providing ideas and references for formulating better treatment strategies.
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Base de dados:
MEDLINE
Assunto principal:
Carcinoma Hepatocelular
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Hepatite B Crônica
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Hepatite B
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Neoplasias Hepáticas
Idioma:
Zh
Ano de publicação:
2024
Tipo de documento:
Article