Environmental Risk Factors, Protective Factors, and Biomarkers for Hearing Loss: An Umbrella Review.
Otolaryngol Head Neck Surg
; 171(2): 323-339, 2024 Aug.
Article
em En
| MEDLINE
| ID: mdl-38520228
ABSTRACT
OBJECTIVE:
We aimed to investigate the potential environmental risk factors, protective factors, and biomarkers of hearing loss (HL), and establish a hierarchy of evidence. DATA SOURCES Embase, PubMed, Cochrane Library, and Web of Science electronic database from inception to June 1, 2023. REVIEWMETHODS:
We included meta-analyses of observational studies of associations between HL and environmental risk factors, protective factors, or biomarkers. We calculated summary effect estimates, 95% confidence interval, heterogeneity I2 statistic, 95% prediction interval, small study effects, and excess significance biases.RESULTS:
Of the 9211 articles retrieved, 60 eligible articles were included. The 60 eligible articles identified 47 potential environmental risk and protective factors (N = 4,123,803) and 46 potential biomarkers (N = 173,701). Evidence of association was convincing (class I) for rheumatoid arthritis (RA) and every 1 cm increase in height. Evidence of association was highly suggestive (class II) for human immunodeficiency virus (HIV), diabetes, cumulative noise exposure (CNE), smoking, congenital cytomegalovirus (CMV) infection, combined exposure to organic solvents and noise, non-Gaussian noise exposure, each 1 kg increase in birth weight, noise exposure, and alopecia areata (AA).CONCLUSION:
In this umbrella review, RA, every 1 cm increase in height, HIV, diabetes, CNE, smoking, congenital CMV infection, combined exposure to organic solvents and noise, non-Gaussian noise exposure, each 1 kg increase in birth weight, noise exposure, and AA were strongly associated with HL.Palavras-chave
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Base de dados:
MEDLINE
Assunto principal:
Biomarcadores
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Fatores de Proteção
/
Perda Auditiva
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article