Pseudomonas putida as a platform for medium-chain length α,ω-diol production: Opportunities and challenges.
Microb Biotechnol
; 17(3): e14423, 2024 Mar.
Article
em En
| MEDLINE
| ID: mdl-38528784
ABSTRACT
Medium-chain-length α,ω-diols (mcl-diols) play an important role in polymer production, traditionally depending on energy-intensive chemical processes. Microbial cell factories offer an alternative, but conventional strains like Escherichia coli and Saccharomyces cerevisiae face challenges in mcl-diol production due to the toxicity of intermediates such as alcohols and acids. Metabolic engineering and synthetic biology enable the engineering of non-model strains for such purposes with P. putida emerging as a promising microbial platform. This study reviews the advancement in diol production using P. putida and proposes a four-module approach for the sustainable production of diols. Despite progress, challenges persist, and this study discusses current obstacles and future opportunities for leveraging P. putida as a microbial cell factory for mcl-diol production. Furthermore, this study highlights the potential of using P. putida as an efficient chassis for diol synthesis.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Pseudomonas putida
/
Poli-Hidroxialcanoatos
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article