Real-world association between systemic corticosteroid exposure and complications in US patients with severe asthma.
Allergy Asthma Clin Immunol
; 20(1): 25, 2024 Mar 26.
Article
em En
| MEDLINE
| ID: mdl-38532489
ABSTRACT
BACKGROUND:
Systemic corticosteroid (SCS) use remains widespread among patients with severe asthma, despite associated complications.OBJECTIVE:
Evaluate the association between cumulative SCS exposure and SCS-related complications in severe asthma.METHODS:
This retrospective, longitudinal study used claims data from the Optum Clinformatics Data Mart database (GSK ID 214469). Eligible patients (≥ 12 years old) had an asthma diagnosis and were divided into two cohorts SCS use and non/burst-SCS use. Patients in the SCS use cohort had a claim for a daily prednisone-equivalent dose ≥ 5 mg SCS following ≥ 6 months of continuous SCS use; those in the non/burst-SCS cohort had no evidence of continuous SCS use and had a non-SCS controller/rescue medication initiation claim. For each cohort, the date of the qualifying claim was the index date. SCS users were further stratified by SCS use during each quarter of follow-up low (≤ 6 mg/day), medium (> 6-12 mg/day), high (> 12 mg/day), and continuous high (≥ 20 mg/day for 90 days). SCS-related complications were evaluated in the quarter following SCS exposure. The adjusted odds ratios (OR) of experiencing SCS-related complications during follow-up in each of the SCS use groups versus the non/burst SCS cohort were calculated using generalized estimating equations models.RESULTS:
SCS and non/burst-SCS use cohorts included 7473 and 89,281 patients (mean follow-up 24.6 and 24.2 months), respectively. Compared with the non/burst-SCS use cohort, medium, high, and continuous high SCS use was associated with greater odds of any SCS-related complication (adjusted OR [95% confidence interval] 1.30 [1.21, 1.39], 1.49 [1.35, 1.64] and 1.63 [1.40, 1.89], respectively) including increased acute gastrointestinal, cardiovascular, and immune system-related complications, and chronic cardiovascular, metabolic/endocrine, central nervous system, bone-/muscle-related, ophthalmologic, and hematologic/oncologic complications. Low-dose SCS use was also associated with significantly increased odds of acute gastrointestinal and immune system-related complications, and chronic bone-/muscle-related and hematologic/oncologic complications versus the non/burst-SCS use cohort.CONCLUSION:
SCS use, even at low doses, is associated with increased risk of SCS-related complications among patients with severe asthma.
Texto completo:
1
Base de dados:
MEDLINE
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article