Role of differentiated embryo-chondrocyte expressed gene 2 in immunity.
Front Immunol
; 15: 1335473, 2024.
Article
em En
| MEDLINE
| ID: mdl-38533496
ABSTRACT
Differentiated embryo-chondrocyte expressed gene 2 (DEC2) is a member of the basic helix-loop-helix (bHLH) subfamily of transcription factors. DEC2 is implicated in tumor immunotherapy, immune system function regulation, and autoimmune diseases. DEC2 enhances Th2 cell differentiation by regulating the IL-2 and IL-4 signaling pathways and mediates the growth of B-1a cells, thereby promoting the occurrence and development of inflammatory responses. In this study, we review the reported roles of DEC2, including the regulation of immune cell differentiation and cytokine production in various cells in humans, and discuss its potential in treating autoimmune diseases and tumors.
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Base de dados:
MEDLINE
Assunto principal:
Doenças Autoimunes
/
Fatores de Transcrição Hélice-Alça-Hélice Básicos
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article