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Desipramine induces anti-inflammatory dorsal root ganglion transcriptional signatures in the murine spared nerve injury model.
Serafini, Randal A; Ramakrishnan, Aarthi; Shen, Li; Zachariou, Venetia.
Afiliação
  • Serafini RA; Nash Family Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY 10029, United States.
  • Ramakrishnan A; Department of Pharmacology, Physiology & Biophysics, Avedisian and Chobanian School of Medicine at Boston University, Boston, MA 02118, United States.
  • Shen L; Nash Family Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY 10029, United States.
  • Zachariou V; Department of Pharmacology, Physiology & Biophysics, Avedisian and Chobanian School of Medicine at Boston University, Boston, MA 02118, United States.
Neurobiol Pain ; 15: 100153, 2024.
Article em En | MEDLINE | ID: mdl-38549875
ABSTRACT
Monoamine-targeting antidepressants serve as frontline medications for chronic pain and associated comorbidities. While persistent anti-allodynic properties of antidepressants generally require weeks of treatment, several groups have demonstrated acute analgesic effects within hours of administration, suggesting a role in non-mesocorticolimbic pain processing regions such as the peripheral nervous system. To further explore this possibility, after four weeks of spared nerve injury or sham surgeries, we systemically administered desipramine or saline for an additional three weeks and performed whole transcriptome RNA sequencing on L3-6 dorsal root ganglia. Along with alterations in molecular pathways associated with neuronal activity, we observed a robust immunomodulatory transcriptional signature in the desipramine treated group. Cell subtype deconvolution predicted that these changes were associated with A- and C-fibers. Of note, differentially expressed genes from the dorsal root ganglia of DMI-treated, injured mice were largely unique compared to those from the nucleus accumbens of the same animals. These observations suggest that, under peripheral nerve injury conditions, desipramine induces specific gene expression changes across various regions of the nociceptive circuitry.
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Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2024 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2024 Tipo de documento: Article