Sympathetic Pathophysiology in Hypertension Origins: The Path to Renal Denervation.
Hypertension
; 81(6): 1194-1205, 2024 Jun.
Article
em En
| MEDLINE
| ID: mdl-38557153
ABSTRACT
The importance of the sympathetic nervous system in essential hypertension has been recognized in 2 eras. The first was in early decades of the 20th century, through to the 1960s. Here, the sympathetic nervous system was identified as a target for the treatment of hypertension, and an extensive range of antiadrenergic therapies were developed. Then, after a period of lapsed interest, in a second era from 1985 on, the development of precise measures of human sympathetic nerve firing and transmitter release allowed demonstration of the importance of neural mechanisms in the initiation and maintenance of the arterial blood pressure elevation in hypertension. This led to the development of a device treatment of hypertension, catheter-based renal denervation, which we will discuss.
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Base de dados:
MEDLINE
Assunto principal:
Simpatectomia
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Sistema Nervoso Simpático
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Hipertensão
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Rim
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article