Blood cellular membrane-coated Au/polydopamine nanoparticle-targeted NIR-II antibacterial therapy.
J Colloid Interface Sci
; 665: 855-862, 2024 Jul.
Article
em En
| MEDLINE
| ID: mdl-38564949
ABSTRACT
Bacterial infections are the primary causes of infectious diseases in humans. In recent years, the abuse of antibiotics has led to the widespread enhancement of bacterial resistance. Concerns have been raised about the identification of a common treatment platform for bacterial infections. In this study, a composite nanomaterial was used for near-infrared II (NIR-II) photothermal antibacterial treatment. Red blood cell membrane was peeled and coated onto the surface of the Au/polydopamine nanoparticle-containing aptamer. The composite nanomaterials based on Au/polydopamine exhibit highest photothermal conversion capability. Moreover, these assembled nanoparticles can quickly enter the body's circular system with a specific capability to recognise bacteria. In vivo experiments demonstrated that the composites could kill bacteria from infected blood while significantly reducing the level of bacteria in various organs. Such assemblies offer a paradigm for the treatment of bacterial infections caused by the side effects of antibiotics.
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Base de dados:
MEDLINE
Assunto principal:
Polímeros
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Infecções Bacterianas
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Nanopartículas
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Indóis
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article