Total Synthesis of Quebrachamine and Kopsiyunnanine D.
J Org Chem
; 89(8): 5905-5910, 2024 Apr 19.
Article
em En
| MEDLINE
| ID: mdl-38579179
ABSTRACT
The total syntheses of (±)-quebrachamine and (±)-kopsiyunnanine D are reported. Key transformations include an intermolecular Horner-Wadsworth-Emmons olefination to merge the two fragments convergently and an intramolecular Mitsunobu reaction to introduce the synthetically challenging nine-membered azonane ring efficiently.
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Base de dados:
MEDLINE
Idioma:
En
Ano de publicação:
2024
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Article