Impact of renal cell carcinoma molecular subtypes on immunotherapy and targeted therapy outcomes.
Cancer Cell
; 42(5): 732-735, 2024 May 13.
Article
em En
| MEDLINE
| ID: mdl-38579722
ABSTRACT
Saliby et al. show that a machine learning approach can accurately classify clear cell renal cell carcinoma (RCC) into distinct molecular subtypes using transcriptomic data. When applied to tumors biospecimens from the JAVELIN Renal 101 (JR101) trial, a benefit is observed with immune checkpoint inhibitor (ICI)-based therapy across all molecular subtypes.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Carcinoma de Células Renais
/
Inibidores de Checkpoint Imunológico
/
Imunoterapia
/
Neoplasias Renais
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article