Nuclear-targeted chimeric peptide nanorods to amplify innate anti-tumor immunity through localized DNA damage and STING activation.

Wu, Yeyang; Li, Yanmei; Yan, Ni; Huang, Jiaqi; Li, Xinyu; Zhang, Keyan; Lu, Zhenming; Qiu, Ziwen; Cheng, Hong

Wu, Yeyang; Li, Yanmei; Yan, Ni; Huang, Jiaqi; Li, Xinyu; Zhang, Keyan; Lu, Zhenming; Qiu, Ziwen; Cheng, Hong.

Afiliação

Wu Y; School of Biomedical Engineering & Guangdong Provincial Key Laboratory of Construction and Detection in Tissue Engineering, Southern Medical University, Guangzhou 510515, PR China.
Li Y; School of Biomedical Engineering & Guangdong Provincial Key Laboratory of Construction and Detection in Tissue Engineering, Southern Medical University, Guangzhou 510515, PR China.
Yan N; School of Biomedical Engineering & Guangdong Provincial Key Laboratory of Construction and Detection in Tissue Engineering, Southern Medical University, Guangzhou 510515, PR China.
Huang J; School of Biomedical Engineering & Guangdong Provincial Key Laboratory of Construction and Detection in Tissue Engineering, Southern Medical University, Guangzhou 510515, PR China.
Li X; School of Biomedical Engineering & Guangdong Provincial Key Laboratory of Construction and Detection in Tissue Engineering, Southern Medical University, Guangzhou 510515, PR China.
Zhang K; School of Biomedical Engineering & Guangdong Provincial Key Laboratory of Construction and Detection in Tissue Engineering, Southern Medical University, Guangzhou 510515, PR China.
Lu Z; School of Biomedical Engineering & Guangdong Provincial Key Laboratory of Construction and Detection in Tissue Engineering, Southern Medical University, Guangzhou 510515, PR China.
Qiu Z; School of Biomedical Engineering & Guangdong Provincial Key Laboratory of Construction and Detection in Tissue Engineering, Southern Medical University, Guangzhou 510515, PR China.
Cheng H; School of Biomedical Engineering & Guangdong Provincial Key Laboratory of Construction and Detection in Tissue Engineering, Southern Medical University, Guangzhou 510515, PR China. Electronic address: chengh@smu.edu.cn.

J Control Release ; 369: 531-544, 2024 May.

Article em En | MEDLINE | ID: mdl-38580138

Assuntos

Dano ao DNA; Imunidade Inata; Proteínas de Membrana; Animais; Imunidade Inata/efeitos dos fármacos; Humanos; Fármacos Fotossensibilizantes/administração & dosagem; Fármacos Fotossensibilizantes/farmacologia; Núcleo Celular/metabolismo; Camundongos Endogâmicos BALB C; Linhagem Celular Tumoral; Nanotubos de Peptídeos/química; Espécies Reativas de Oxigênio/metabolismo; Neoplasias Pulmonares/imunologia; Neoplasias Pulmonares/terapia; Neoplasias Pulmonares/tratamento farmacológico; Feminino; Camundongos; Neoplasias/imunologia; Neoplasias/terapia; Neoplasias/tratamento farmacológico; Antineoplásicos/administração & dosagem; Antineoplásicos/farmacologia; Células Matadoras Naturais/imunologia; Células Matadoras Naturais/efeitos dos fármacos; Peptídeos/administração & dosagem; Peptídeos/química

Palavras-chave

Immunologic cell death; Innate immunity; Nuclear targeting; Photodynamic therapy; cGAS/STING pathway

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Dano ao DNA / Imunidade Inata / Proteínas de Membrana Idioma: En Ano de publicação: 2024 Tipo de documento: Article

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