The PLA2 inhibitor from Crotalus durissus terrificus blood plasma (CNF) inhibits group III-PLA2 from honeybee venom.
Toxicon
; 242: 107711, 2024 May 06.
Article
em En
| MEDLINE
| ID: mdl-38583578
ABSTRACT
Crotalus neutralizing factor (CNF) is an endogenous glycoprotein from Crotalus durissus terrificus snake blood that inhibits secretory phospholipases A2 (sPLA2) from the Viperid but not from Elapid venoms (subgroups IA and IIA, respectively). In the present study, we demonstrated that CNF can inhibit group III-PLA2 from bee venom by forming a stable enzyme-inhibitor complex. This finding opens up new possibilities for the potential use of CNF and/or CNF-based derivatives in the therapeutics of bee stings.
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Base de dados:
MEDLINE
Assunto principal:
Venenos de Abelha
/
Crotalus
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Serpentes Peçonhentas
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article