Melatonin receptor structure and signaling.
J Pineal Res
; 76(3): e12952, 2024 Apr.
Article
em En
| MEDLINE
| ID: mdl-38587234
ABSTRACT
Melatonin (5-methoxy-N-acetyltryptamine) binds with high affinity and specificity to membrane receptors. Several receptor subtypes exist in different species, of which the mammalian MT1 and MT2 receptors are the best-characterized. They are members of the G protein-coupled receptor superfamily, preferentially coupling to Gi/o proteins but also to other G proteins in a cell-context-depending manner. In this review, experts on melatonin receptors will summarize the current state of the field. We briefly report on the discovery and classification of melatonin receptors, then focus on the molecular structure of human MT1 and MT2 receptors and highlight the importance of molecular simulations to identify new ligands and to understand the structural dynamics of these receptors. We then describe the state-of-the-art of the intracellular signaling pathways activated by melatonin receptors and their complexes. Brief statements on the molecular toolbox available for melatonin receptor studies and future perspectives will round-up this review.
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Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Receptor MT1 de Melatonina
/
Melatonina
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article