Visible-Light-Mediated Three-Component Strategy for the Synthesis of Isoxazolines and Isoxazoles.
Org Lett
; 26(15): 3130-3134, 2024 Apr 19.
Article
em En
| MEDLINE
| ID: mdl-38587308
ABSTRACT
Isoxazolines and isoxazoles commonly serve as core structures of many therapeutic agents and natural products. However, the metal-free and catalysis-free strategy for the synthesis of these privileged motifs at room temperature remains a challenging task. Herein, we report a three-component strategy to afford diverse isoxazolines and isoxazoles via [3 + 2] cycloadditions of in situ-formed nitronates and olefins/alkynes under visible-light irradiation.
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MEDLINE
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En
Ano de publicação:
2024
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Article