Comparison of in vitro Toxicities of 8-Prenylnaringenin, Tartrazine and 17ß-Estradiol, Representatives of Natural and Synthetic Estrogens, in Rat and Human Hepatoma Cell Lines.
Endocr Res
; 49(2): 106-116, 2024.
Article
em En
| MEDLINE
| ID: mdl-38597376
ABSTRACT
BACKGROUND:
Phytoestrogens have been praised for their beneficial health effects, whereas synthetic xenoestrogens have been connected to ailments.AIMS:
To ascertain whether the toxicities of natural and synthetic estrogens differ, we examined the potent phytoestrogen 8-prenylnaringenin (8-PN), the common synthetic xenoestrogen tartrazine, and the physiological estrogen 17ß-estradiol (E2).METHODS:
These three compounds were tested for cytotoxicity, cell proliferation and genotoxicity in human HepG2 and rat H4IIE hepatoma cells.RESULTS:
All three estrogens elicited cytotoxicity at high concentrations in both cell lines. They also inhibited cell proliferation, with E2 being the most effective. They all tended to increase micronuclei formation.CONCLUSION:
Natural estrogens were no less toxic than a synthetic one.Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Tartrazina
/
Flavanonas
/
Proliferação de Células
/
Estradiol
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article