Ortho C-H Bond Activations in an Atmospheric Microwave Plasma Ion Source.
J Am Soc Mass Spectrom
; 35(5): 951-959, 2024 May 01.
Article
em En
| MEDLINE
| ID: mdl-38597607
ABSTRACT
C-H bond ortho-substitution reaction has always been a significant and challenging topic in organic chemistry. We proposed a synthesis method based on microwave plasma torches. High-resolution mass spectrometry was used to monitor rapid reaction products. 2-Alkylbenzimidazole can be formed through the reaction of phenylnitrenium ion and nitriles on a millisecond scale. This reaction can achieve the one-step formation of benzimidazoles from benzene ring single-substituted compounds without the addition of external oxidants or catalysts. A similar C-H bond activation reaction can be accomplished with ketones. Meanwhile, the microwave plasma reactor was modified, and the resulting 2-methylbenzimidazole was successfully collected, indicating the device has good application potential in organic reactions such as C-H bond activation reaction.
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MEDLINE
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Ano de publicação:
2024
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Article